<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Strict//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-strict.dtd"><html xmlns="http://www.w3.org/1999/xhtml"><head><title>R: Effects of Serotonin in Mice</title>
<meta http-equiv="Content-Type" content="text/html; charset=utf-8" />
<link rel="stylesheet" type="text/css" href="R.css" />
</head><body>

<table width="100%" summary="page for MouseBrain"><tr><td>MouseBrain</td><td style="text-align: right;">R Documentation</td></tr></table>

<h2>Effects of Serotonin in Mice</h2>

<h3>Description</h3>

<p>Effects of altering serotonin levels on social interactions of mice
</p>


<h3>Format</h3>

<p>A data frame with 48 observations on the following 3 variables.
</p>

<dl>
<dt><code>Contacts</code></dt><dd><p>Number of social contacts the mouse had during the experiment</p>
</dd>
<dt><code>Sex</code></dt><dd> <p><code>F</code>=female or <code>M</code>=male</p>
</dd>
<dt><code>Genotype</code></dt><dd><p><code>Minus</code>, <code>Mixed</code>, or <code>Plus</code> (see description below)</p>
</dd>
</dl>



<h3>Details</h3>

<p>Serotonin is a chemical that influences mood balance in humans. But how does it affect mice? Scientists genetically altered mice by &quot;knocking out&quot; the expression of a gene, tryptophan hydroxylase 2 (Tph2), that regulates serotonin production. With careful breeding, the scientists produced three types of mice that we label as &ldquo;Minus&rdquo; for Tph2-/-, &ldquo;Plus&rdquo; for Tph2+/+, &ldquo;Mixed&rdquo; for Tph2+/-. The variable Genotype records Minus/Plus/Mixed. The variable Contacts is the number of social contacts that a mouse had with other mice during an experiment and the variable Sex is &ldquo;M&rdquo; for males and &ldquo;F&rdquo; for females.
</p>


<h3>Source</h3>

<p>Beis D, Holzwarth K, Flinders M, Bader M, Wohr M, Alenina N., (2015) &quot;Brain serotonin deficiency leads to social communication deficits in mice,&quot; Biol. Lett. 11:20150057. <br />
http://dx.doi.org/10.1098/rsbl.2015.0057
</p>
<p>Once you go to the above link, to get the data, click on the &quot;Figures and Data&quot; tab.  Then click on the &quot;Juvenile SocInter Behavior Data&quot; link to download a hairy data file that needs to be cleaned a great deal to get our data.
</p>


</body></html>
